Thankfully there are too many good sounds for them to make much of an impact on the actual artform - but instead these tedious Victorian policeman-look-alikes have targeted the delivery format. And of course they have had a fair go at messing with music too. They have ruined beer, coffee, tattoos and facial hair. It’s not a book I’ll be taking to a charity shop or passing to a friend as it’s nice to dip into and I probably will in the future, it's also a book I'd be pleased to receive as a gift (with Christmas almost upon us), but as a real good read it falls short. I guess because Vinyl Me Please is an exclusively vinyl club (I assume - I hadn’t heard of it until this book) then yeah they want you to experience it on vinyl but the only statement that really comes close to making me want to grab a slab ‘o’ wax is in the review of Springsteen’s Nebraska where the reviewer says “For a better rendition of that precious recording quality, this album will always sound better on vinyl”, which at least gives an insight and support behind the reasoning of the book title. I like the associated and occasional recommendation of what drink to listen to the music with - it’s fun….and maybe that’ll expand my options as it’s usually wine or a beer for me.īut at the end of the day it fails to convince me why I should get these on vinyl rather than say CD and I have to ask if it would preach to the unconverted effectively. Sometimes things are left hanging, the Beyonce review where it is said that the surprise release of her fifth album “changed the way the industry conceived of major label album releases”, and it goes on to say that other artists attempted to pull off the same feat, but it doesn’t explain what this feat was and as Beyonce doesn’t really come into my sphere of listening I would have liked to have known what her devotees know. The reviews are not quite compelling enough and I know it’s super hard to enthuse to someone about something you love especially when faced with a blank page to fill with words but I feel most reviews need that little extra to push them over the edge. The overviews are pretty good but only a handful have had me thinking “I’ll have to check that out”. There also seems to be a lot of white space, space which could have been filled with slightly more in depth appraisals of the albums. The book itself is okay, it’s a nice size, just the front sleeves are shown which is a pity maybe the inserts or rear sleeves might have made it a bit more engaging and there is a synopsis of each album. Playing it is also more of a ritual getting the record out, holding it reverently by the edges maybe giving it a quick clean … then that pregnant pause between lowering the stylus and it hitting the record after which you immerse yourself in the music and the sleeve, a ritual probably associated closely with people of a certain age but easily addictive to younger folk I’ve found and one that diminishes with presumably “lesser” formats. I love vinyl, I’ve a ton of the stuff along with a ton of CDs and the vinyl vs CD vs download debate could fill all Amazons servers but to keep it simple, vinyl just sounds different. To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice.ġ00 Albums You Need on Vinyl and Why…well there’s 100 albums here but the persuasion for getting them on vinyl is lacking. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. Click ‘Customise Cookies’ to decline these cookies, make more detailed choices, or learn more. Third parties use cookies for their purposes of displaying and measuring personalised ads, generating audience insights, and developing and improving products. This includes using first- and third-party cookies, which store or access standard device information such as a unique identifier. If you agree, we’ll also use cookies to complement your shopping experience across the Amazon stores as described in our Cookie Notice. We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie Notice.
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The manufacturing of CAR T-cell therapies involves the removal of T-cells from a patient’s blood. TCRs are specifically modified proteins for a particular type of cancer, which enables T-cells to recognise and kill antigens expressed by the tumour cells. CAR T-cell therapies are one-time treatments produced from a patient’s white blood cells or T-cells.ĬARs are engineered proteins that contain an antibody or target-binding component to identify the specific antigen expressed by the tumour cells and other signal-activating components for T-cells to kill tumour cells. Kite Pharma develops T-cell-based cancer immunotherapies for oncology by using a chimeric antigen receptor (CAR) or a T-cell receptor (TCR), based on the type of cancer. It also supports the production of KITE-718 therapy. The facility develops a replication-deficient lentiviral vector, which is used to produce an investigational biologic candidate KITE-585. The retroviral vector PG13-CD19-H3 is also used for the development of other investigational therapy candidates such as KTE-X19 for acute lymphocytic leukaemia and mantle cell lymphoma. T-cells from the WBCs are extracted, modified and re-infused into the patients to identify and kill cancer cells. Yescarta is developed from the patient’s own white blood cells (WBCs). It was the company’s first CAR T-cell therapy that was approved by the FDA in 2017 and is used for the treatment of large B-cell lymphoma in adult patients. PG13-CD19-H3 is the important starting material used to produce Yescarta. The new facility is dedicated to the manufacture of viral vectors such as replication-deficient gamma-retroviral vector PG13-CD19-H3 and replication-deficient lentiviral vector. The facility is staffed by a team of experts and operates under stringent regulatory guidelines to ensure that the finished products are safe, pure, and effective. The state-of-the-art viral vector manufacturing facility is a 100,000ft² building focused on the development and production of viral vectors in-house for pre-clinical or early-stage clinical trials, as well as commercial use. Kite Pharma’s viral vector manufacturing facility details In March 2022, Gilead purchased approximately 27 acres of land in Oceanside, next to the existing facility to support future manufacturing operations. Oceanside can be accessed through three highways, I-5, Highway 78, and Highway 76. Situated between Los Angeles and San Diego, Oceanside is connected to Los Angeles by Interstate I-405 South and to San Diego by Interstate I-5 North. The facility was purchased from Genentech in August 2011. The viral vector manufacturing facility is located within Gilead’s existing biologics operation facility at 4049 Avenida de la Plata, Oceanside. Not all patients will experience the same results.Location of the viral vector manufacturing facility "It's not so much the odds you're looking for, it's the hope." "When you have cancer, it's a game of percentages," said Shon. That helped Shon and Lisa maintain a positive attitude and stay optimistic about life. Throughout their journey with cancer, hope remained the common theme With CAR T, he was excited to discover an option that takes his own T cells and engineers them to fight the cancer cells in his body.Īfter talking to his doctor, Shon and his wife made the decision to try CAR T. His oncologist, he was intrigued and wanted to learn more. When he heard about CAR T-cell therapy from "What’s my weapon? What’s in my toolbox?" he remembers asking. In that moment, they felt defeated, like they had exhausted all of their options in their battle against cancer.īut Shon didn’t give up hope. After learning that two lines of chemotherapy to treat his diffuse large B-cell lymphoma (DLBCL) had failed, Shon and his wife, Lisa, were devastated. Prince Salman has now added yet another geopolitical component: The massive imports of hydrogen from the Middle East and North Africa are to be directed to Europe via Greece. Greece is, so to speak, predestined and privileged. In all other cases, either one or the other predominates. Together with Portugal, Greece is one of the two European countries that have an equally high potential for windenergy and solarenergy. This becomes very clear in Western Macedonia, where lignite is actually to be completely replaced by renewables in combination with hydrogen. Indeed, hydrogen has the potential to transform Greece from an energy importer into a self-sufficient, energy autonomous country, with renewableenergy replacing the previously dominant fossil based energy. The White Dragon project and its project coordinators triggered an initial effect that brought many companies to work together for the first time and set off for new shores. More will follow, meanwhile top-class greek companies with a keen interest in hydrogen are bustling about in Greece, which at the same time represents the who’s who of the Greek economy. The Greek government was actively involved and achieved great success in July when two projects within the framework of the so-called ipcei (important projects of common European interest) were recognized by the European Commission in the first phase. Indeed, since the announcement of the WhiteDragon project in Western Macedonia, Greece has been on the European map of hydrogen projects. This was new for many, surprising and seemed like a glimpse of the future. Greece is to become the European hub for hydrogen. Relations are historically and traditionally good, but now a new phase is to be heralded. It was like a bang when Prince Mohammed bin Salman assessed his country’s relationship with Greece during his joint appearance with the Greek Prime Minister Kyriakos Mitsotakis. Visit Kia of Stockton for more information. Android Auto and Apple CarPlay come standard, and Harman/Kardon audio is built in. This touchscreen hosts many applications that are accessed by touching the screen. Located in the center dash is a 10.25-inch touchscreen. Tests show that the new Soul reaches 60 mph in an estimated 8.0 seconds on the interstate around Modesto. This four-cylinder engine produces 147 horsepower and 132 pound-feet of torque. This includes Blind Spot Collision Warning, Forward Collison-Avoidance Assist, and Smart Cruise Control.Ī smooth drive is delivered by the vehicle's 2.0-liter engine. Several driver-assistance features are built in for preventive safety measures. The 2023 Kia Soul goes further by keeping all passengers safe and secure while traveling. The new Kia Soul yields 62.1 cubic feet of cargo volume when the rear seats are folded down. At Cole Kia you will find a large inventory of the latest new Kia models. The crossover's rear seats have split-fold capability, which helps to unlock more cargo space. New Kia Cars and SUVs For Sale in Bluefield, WV. Five people sit in the cabin while enjoying 120.9 cubic feet of passenger volume. At the base level, the Kia Soul LX is priced at just 19,790. Our inventory includes the LX, S, GT-Line, and EX. New Kia Seltos InventoryGet Pre-Approved For Financing. Here at in Stockton, we carry several trim levels. You want to know what is one of the most popular vehicles in South Central Minnesota It is the Kia Soul. SynTex material is available, but your trim choice dictates the fabric. The all-new 2023 Kia Soul will feature a single 2-liter 4-cylinder engine for. A sufficient amount of comfort is also found in the cabin via woven or tricot cloth. Model Research 2023 Kia Models 2023 Kia Soul. Interested buyers can expect an abundance of technological innovation, which is handy for passenger engagement. There has never been a better time to find this SUV in our new inventory. The powertrain debuted with a 109 bhp motor, but Kia later introduced a 201 bhp electric motor with its 2019 Soul EV. It comes with a unique set of 16-inch alloy wheels and a lighter colour trim in its interior. In addition to that, the new Kia Soul sports more modern headlamps. Yes, Kia offers the Kia Soul EV model, which rivals the Nissan Leaf and Hyundai Ioniq. The vehicle sits well-balanced on 17- and 18-inch wheels. This popular crossover comes with some automotive refreshments, from a new grille to new bumper designs for its exterior. Except for the automatic-only Soul Sport, all Souls have a six-speed manual gearbox as standard, with certain diesels offering a seven-speed automatic option at extra cost.The 2023 Kia Soul is back in the headlines, and it's garnering plenty of attention. The Sport version takes things too far though, with a firm and unsettled ride that doesn’t feel suited to bumpy British roads.Ī powerful 201bhp 1.6-litre T-GDI turbocharged petrol engine brings an extra dimension of performance compared to the 134bhp diesel model, while there is also a 130bhp 1.6-litre petrol – the only engine available for the entry-level '1' model. There’s good visibility forward, too, so you can see a long way ahead from that high driving position. Despite its height, it doesn’t lean into corners like you might expect, and the big wheels grip the road tightly. This incentive is a limited time offer on eligible Kia vehicles. In any trim, it may not look like the most dynamic of vehicles, but the Soul doesn’t actually give the driver too much of a raw deal. The Soul Sport gets a sporty front bumper and grille, twin exhaust tailpipes and unique 18-inch alloy wheels, while the interior has its own colour scheme and a flat-bottomed steering wheel. It’s a similar story inside, where metallic trim contrasts nicely with piano-black inserts. Styling updates from 2016 included a revamped nose with Kia’s ‘tiger-nose’ family grille, xenon headlights and LED daytime running lights and large front foglights have brought the Soul up to date. The Soul’s tall roof and boxy shape mean storage and boot space is good, but the Renault Captur or Skoda Karoq offer a little more room in these areas. Its large windows brighten up the interior, even for rear seat passengers and its high seating position allowed for a great view of the road, while still offering lots of head and knee room. The Soul was designed from its original concept to have a squared-off design, helping practicality. A facelift in 2016 helped the car keep pace with rivals, as did the addition of a 201bhp model called the Kia Soul Sport in 2017. The Kia Soul is a rival for the Nissan Juke, Citroen C3 Aircross and the Renault Captur. The current Soul still retains the quirky styling of the original model, but it is now only available as a pure-electric EV model, which we’ve reviewed separately. When Kia Soul crossover was launched around a decade ago, it was a surprising departure from the South Korean manufacturer’s usual cars. Our top priority is protecting the privacy of our users, so we offer a safe and secure environment for Download From Facebook. We don’t support illegal usage of the videos, nor do we promote such an act. You can download Facebook videos through our Download From Facebook online tool for personal reasons only. It won’t let you save videos from private accounts. The Download From Facebook only allows you to save videos from public accounts. It isn’t illegal to download videos from Facebook unless you are doing it for commercial reasons or copyright infringement. Is it Illegal to Download Videos from Facebook? Enjoy hassle-free and watermark-free Download From Facebook with SaveFrom. 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Please stay off the phone lines throughout the afternoon.” We would be passing heavy current through the lines to overhaul the system. Say something ridiculous like, “My company has slated a phone line overhaul for today. Call a random office and tell them that you’re coming from the phone repair company. This trick is a bit unconventional, but if you pull it off properly, you’re sure to score a couple of laughs. They’d be so confused that they wouldn’t even know what to say. After a while, call them back and say that you’re Mr Jim and ask them if there are any messages for you. Repeat this a couple of times throughout the day. Call any random number but store the number, as you will be calling the person multiple times.Īsk for Mr Jim, then when the person says it isn’t him, tell them “Wrong number,” and hang up the phone. This trick will work if you have the patience to pull it off. Try getting a pizza from Krispy Kreme or a box of tacos from Dominos, and wait for the shock in their responses. Call up any restaurant or food outlet and request food that they don’t serve. It works so well because food outlets have no choice but to engage you in conversation. This prank is one of the most comical tricks in the book. If they say yes, tell them, “You better go catch it!” Tacos from Krispy Kreme? Call a random person and ask if their refrigerator is running. In all honesty, this joke probably won’t work on many people, but that’s what makes it more hilarious. To spice things up, you could add statements like, “how could you forget about me?” or “has it been that long?” Is Your Refrigerator Running? They will eventually get annoyed and hang up. They will probably ask you for your identity and how you got their number but ignore those questions and continue the conversation casually. Call a random number and ask them how they are doing. 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Students learn to speak, read, and write in two languages, and also learn about other cultures while developing strong self-esteem and diverse language skills. For example in a 90% to 10% model, a greater percentage of the instruction is in the target language other than English and decrease over time until reaching 50% to 50%. However, there are other time configurations that exist. In the majority of dual language programs, the students receive half of their instruction in their primary or home language, and the remainder of their instruction in the target language, the language that they are learning. Dual Language Programsĭual Language (DL) programs seek to offer students the opportunity to become bilingual, biliterate, and bicultural while improving their academic ability. 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