![]() ![]() The manufacturing of CAR T-cell therapies involves the removal of T-cells from a patient’s blood. TCRs are specifically modified proteins for a particular type of cancer, which enables T-cells to recognise and kill antigens expressed by the tumour cells. CAR T-cell therapies are one-time treatments produced from a patient’s white blood cells or T-cells.ĬARs are engineered proteins that contain an antibody or target-binding component to identify the specific antigen expressed by the tumour cells and other signal-activating components for T-cells to kill tumour cells. Kite Pharma develops T-cell-based cancer immunotherapies for oncology by using a chimeric antigen receptor (CAR) or a T-cell receptor (TCR), based on the type of cancer. It also supports the production of KITE-718 therapy. The facility develops a replication-deficient lentiviral vector, which is used to produce an investigational biologic candidate KITE-585. The retroviral vector PG13-CD19-H3 is also used for the development of other investigational therapy candidates such as KTE-X19 for acute lymphocytic leukaemia and mantle cell lymphoma. T-cells from the WBCs are extracted, modified and re-infused into the patients to identify and kill cancer cells. Yescarta is developed from the patient’s own white blood cells (WBCs). It was the company’s first CAR T-cell therapy that was approved by the FDA in 2017 and is used for the treatment of large B-cell lymphoma in adult patients. PG13-CD19-H3 is the important starting material used to produce Yescarta. The new facility is dedicated to the manufacture of viral vectors such as replication-deficient gamma-retroviral vector PG13-CD19-H3 and replication-deficient lentiviral vector. The facility is staffed by a team of experts and operates under stringent regulatory guidelines to ensure that the finished products are safe, pure, and effective. The state-of-the-art viral vector manufacturing facility is a 100,000ft² building focused on the development and production of viral vectors in-house for pre-clinical or early-stage clinical trials, as well as commercial use. Kite Pharma’s viral vector manufacturing facility details ![]() In March 2022, Gilead purchased approximately 27 acres of land in Oceanside, next to the existing facility to support future manufacturing operations. Oceanside can be accessed through three highways, I-5, Highway 78, and Highway 76. Situated between Los Angeles and San Diego, Oceanside is connected to Los Angeles by Interstate I-405 South and to San Diego by Interstate I-5 North. The facility was purchased from Genentech in August 2011. The viral vector manufacturing facility is located within Gilead’s existing biologics operation facility at 4049 Avenida de la Plata, Oceanside. Not all patients will experience the same results.Location of the viral vector manufacturing facility "It's not so much the odds you're looking for, it's the hope." "When you have cancer, it's a game of percentages," said Shon. That helped Shon and Lisa maintain a positive attitude and stay optimistic about life. Throughout their journey with cancer, hope remained the common theme ![]() With CAR T, he was excited to discover an option that takes his own T cells and engineers them to fight the cancer cells in his body.Īfter talking to his doctor, Shon and his wife made the decision to try CAR T. His oncologist, he was intrigued and wanted to learn more. When he heard about CAR T-cell therapy from "What’s my weapon? What’s in my toolbox?" he remembers asking. In that moment, they felt defeated, like they had exhausted all of their options in their battle against cancer.īut Shon didn’t give up hope. After learning that two lines of chemotherapy to treat his diffuse large B-cell lymphoma (DLBCL) had failed, Shon and his wife, Lisa, were devastated. ![]()
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